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bioRxiv · 10.1101/2020.03.20.999730

Identification of antiviral drug candidates against SARS-CoV-2 from FDA-approved drugs

Jeon, S.·Ko, M.·Lee, J.·Choi, I.·Byun, S. Y.·Park, S.·Shum, D.·Kim, S.
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Abstract

COVID-19 is an emerging infectious disease and was recently declared as a pandemic by WHO. Currently, there is no vaccine or therapeutic available for this disease. Drug repositioning represents the only feasible option to address this global challenge and a panel of 48 FDA-approved drugs that have been pre-selected by an assay of SARS-CoV was screened to identify potential antiviral drug candidates against SARS-CoV-2 infection. We found a total of 24 drugs which exhibited antiviral efficacy (0.1 M < IC50 < 10 M) against SARS-CoV-2. In particular, two FDA-approved drugs - niclosamide and ciclesonide - were notable in some respects. These drugs will be tested in an appropriate animal model for their antiviral activities. In near future, these already FDA-approved drugs could be further developed following clinical trials in order to provide additional therapeutic options for patients with COVID-19.

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Jeon, S., Ko, M., Lee, J., Choi, I., Byun, S. Y., Park, S., Shum, D., Kim, S.. 2020-03-20. Identification of antiviral drug candidates against SARS-CoV-2 from FDA-approved drugs. https://doi.org/10.1101/2020.03.20.999730

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