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bioRxiv · 10.1101/2020.03.17.996090

A role for the cortex in sleep-wake regulation

Krone, L. B.·Yamagata, T.·Blanco-Duque, C.·Guillaumin, M. C. C.·Kahn, M. C.·Akerman, C. J.·Hoerder-Suabedissen, A.·Molnar, Z.·Vyazovskiy, V. V.
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Abstract

The cortex and subcortical circuitry are thought to play distinct roles in the generation of sleep oscillations and global control of vigilance states. Here we silenced a subset of cortical layer 5 pyramidal and dentate gyrus granule cells in mice using a cell-specific ablation of the key t-SNARE protein SNAP25. We found a marked increase in wakefulness accompanied by a reduced rebound of EEG slow-wave activity after sleep deprivation. Our data illustrates an important role for the cortex in both global state control and sleep homeostasis.

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Krone, L. B., Yamagata, T., Blanco-Duque, C., Guillaumin, M. C. C., Kahn, M. C., Akerman, C. J., Hoerder-Suabedissen, A., Molnar, Z., Vyazovskiy, V. V.. 2020-03-18. A role for the cortex in sleep-wake regulation. https://doi.org/10.1101/2020.03.17.996090

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