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bioRxiv · 10.1101/2020.03.06.981068

Patterns of functional and structural brain information are preserved over generations

Takagi, Y.·Okada, N.·Ando, S.·Yahata, N.·Morita, K.·Koshiyama, D.·Kawakami, S.·Sawada, K.·Koike, S.·Endo, K.·Yamasaki, S.·Nishida, A.·Kasai, K.·Tanaka, S. C.
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Abstract

There is clear evidence of intergenerational transmission of life values, cognitive traits, psychiatric disorders, and even aspects of daily decision making. To investigate biological substrates of this phenomenon, brain has received increasing attention as a measurable biomarker and potential target for intervention. However, no previous study has quantitatively and comprehensively investigated the effects of intergenerational transmission on functional and structural brain networks from parents to their children. Here, by employing an unusually large cohort dataset, we show that patterns of functional and structural brain networks are preserved over a generation. We also demonstrate that several demographic and behavioural phenotypes have effects on brain similarity. Collectively, our results provide a comprehensive picture of neurobiological substrates of parent-child similarity, and demonstrate the usability of our dataset for investigating the neurobiological substrates of intergenerational transmission.

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Takagi, Y., Okada, N., Ando, S., Yahata, N., Morita, K., Koshiyama, D., Kawakami, S., Sawada, K., Koike, S., Endo, K., Yamasaki, S., Nishida, A., Kasai, K., Tanaka, S. C.. 2020-03-08. Patterns of functional and structural brain information are preserved over generations. https://doi.org/10.1101/2020.03.06.981068

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