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bioRxiv · 10.1101/2020.03.04.976522

Recombinant Protein IGF1-24 Stimulates Rat Cardiomyocytes Proliferation and Repairs Myocardial Injury

WANG, X.·Fu, M.·Yi, Q.·Feng, J.·Liao, Y.·Xu, X.·Chen, Y.·Zhang, L.·Sun, H.·Liu, P.·Liang, Y.·Tang, l.
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Abstract

Mammal cardiomyocytes lose their ability of regeneration shortly after birth. Reduced cardiomyocytes number caused by myocardial damage is unable to reverse in current clinical therapies. Therefore, it is important and urgent to find new approaches to stimulate cardiomyocytes regeneration. Here we design a recombinant protein IGF1-24 and show that it triggers cardiomyocytes proliferation in rat. 7 days after tail intravenous injection of IGF1-24, 6-7-weeks-old healthy rats showed marked improvements in cardiomyocytes proliferation. Next, we injured rats cardiac with isoproterenol and treated them with IGF1-24 injection. We found that it efficiently induced cell proliferation with significant improvements in heart histology. These results show that the recombinant IGF1-24 stimulates cardiomyocytes proliferation and can be used to achieve cardiac repair through stimulating endogenous cardiomyocyte proliferation in rats. The IGF 1-24 could be a prospective medicine to heart repair because it has high efficiency in triggering cell proliferation and it can be easily applied to heart by intravenous injection

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WANG, X., Fu, M., Yi, Q., Feng, J., Liao, Y., Xu, X., Chen, Y., Zhang, L., Sun, H., Liu, P., Liang, Y., Tang, l.. 2020-03-05. Recombinant Protein IGF1-24 Stimulates Rat Cardiomyocytes Proliferation and Repairs Myocardial Injury. https://doi.org/10.1101/2020.03.04.976522

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