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bioRxiv · 10.1101/2020.02.27.969048

Manganese complex Br increases antibiotic sensitivity in multidrug resistant Streptococcus pneumoniae

Liakopoulos, A.·LaRagione, R.·Nagel, C.·Schatzschneider, U.·Rozen, D.·Betts, J. W.
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Abstract

The emergence of multidrug-resistance (MDR) in Streptococcus pneumoniae clones and non-vaccine serotypes is of increasing concern, necessitating the development of novel treatment strategies. Here, we determined the efficacy of the Mn complex [Mn(CO)3(tpa-{kappa}3N)]Br against MDR S. pneumoniae strains. Our data showed that [Mn(CO)3(tpa-{kappa}3N)]Br has in vitro and in vivo antibacterial activity and has the potential to be used in combination with currently available antibiotics to increase their effectiveness against MDR S. pneumoniae.

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Liakopoulos, A., LaRagione, R., Nagel, C., Schatzschneider, U., Rozen, D., Betts, J. W.. 2020-03-01. Manganese complex Br increases antibiotic sensitivity in multidrug resistant Streptococcus pneumoniae. https://doi.org/10.1101/2020.02.27.969048

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