Anopheles stephensi as an emerging malaria vector in the Horn of Africa with high susceptibility to Ethiopian Plasmodium vivax and Plasmodium falciparum isolates

Amenu, T. A.; Teka, H.; Esayas, E.; Messenger, L. A.; Chali, W.; Meerstein-Kessel, L.; Walker, T.; Behaksra, S. W.; Lanke, K.; Heutink, R.; Jeffries, C. L.; Mekonnen, D. A.; Hailemeskel, E.; Tafesse, T.; Gashaw, A.; Tsegaye, T.; Emiru, T.; Simon, K.; Bogale, E. A.; Yohannes, G.; Kedir, S.; Shumie, G.; Sabir, S. A.; Mumba, P.; Dengela, D.; Kolaczinski, J. H.; Wilson, A.; Churcher, T. S.; Chibsa, S.; Murphy, M.; Balkew, M.; Irish, S.; Drakeley, C.; Gadisa, E.; Bousema, T.; Tadesse, F. G.

doi:10.1101/2020.02.22.961284

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bioRxiv · 10.1101/2020.02.22.961284

Anopheles stephensi as an emerging malaria vector in the Horn of Africa with high susceptibility to Ethiopian Plasmodium vivax and Plasmodium falciparum isolates

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Abstract

Anopheles stephensi, an efficient Asian malaria vector, recently spread into the Horn of Africa and may increase malaria receptivity in African urban areas. We assessed occurrence, genetic complexity, blood meal source and infection status of An. stephensi in Awash Sebat Kilo town, Ethiopia. We used membrane feeding assays to assess competence of local An. stephensi to P. vivax and P. falciparum isolates from clinical patients. 75.3% of the examined waterbodies were infested with An. stephensi developmental stages that were genetically closely related to isolates from Djibouti and Pakistan. Both P. vivax and P. falciparum were detected in wild-caught adult An. stephensi. Local An. stephensi was more receptive to P. vivax compared to a colony of An. arabiensis. We conclude that An. stephensi is an established vector in this part of Ethiopia, highly permissive for local P. vivax and P. falciparum isolates and presents an important new challenge for malaria control. Summary of the articleAn. stephensi, a metropolitan malaria vector that recently expanded to the Horn of African, was highly susceptible to local P. falciparum and P. vivax isolates from Ethiopia and may increase malariogenic potential of rapidly expanding urban settings in Africa.

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Amenu, T. A., Teka, H., Esayas, E., Messenger, L. A., Chali, W., Meerstein-Kessel, L., Walker, T., Behaksra, S. W., Lanke, K., Heutink, R., Jeffries, C. L., Mekonnen, D. A., Hailemeskel, E., Tafesse, T., Gashaw, A., Tsegaye, T., Emiru, T., Simon, K., Bogale, E. A., Yohannes, G., Kedir, S., Shumie, G., Sabir, S. A., Mumba, P., Dengela, D., Kolaczinski, J. H., Wilson, A., Churcher, T. S., Chibsa, S., Murphy, M., Balkew, M., Irish, S., Drakeley, C., Gadisa, E., Bousema, T., Tadesse, F. G.. 2020-02-25. Anopheles stephensi as an emerging malaria vector in the Horn of Africa with high susceptibility to Ethiopian Plasmodium vivax and Plasmodium falciparum isolates. https://doi.org/10.1101/2020.02.22.961284

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