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bioRxiv · 10.1101/2020.02.14.948356

Central vestibular tuning arises from patterned convergence of otolith afferents

Abstract

As sensory information moves through the brain, higher-order areas exhibit more complex tuning than lower areas. Though models predict this complexity is due to convergent inputs from neurons with diverse response properties, in most vertebrate systems convergence has only been inferred rather than tested directly. Here we measure sensory computations in zebrafish vestibular neurons across multiple axes in vivo. We establish that whole-cell physiological recordings reveal tuning of individual vestibular afferent inputs and their postsynaptic targets. An independent approach, serial section electron microscopy, supports the inferred connectivity. We find that afferents with similar or differing preferred directions converge on central vestibular neurons, conferring more simple or complex tuning, respectively. Our data also resolve a long-standing contradiction between anatomical and physiological analyses by revealing that sensory responses are produced by sparse but powerful inputs from vestibular afferents. Together these results provide a direct, quantifiable demonstration of feedforward input convergence in vivo.

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Liu, Z., Kimura, Y., Higashijima, S.-i., Hildebrand, D., Morgan, J., Holy, T., Bagnall, M. W.. 2020-02-15. Central vestibular tuning arises from patterned convergence of otolith afferents. https://doi.org/10.1101/2020.02.14.948356

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