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bioRxiv · 10.1101/2020.02.09.940726

Structural variation in hippocampal dentations among healthy young adults

ten Hove, J.·Poppenk, J.
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Abstract

Little is known about hippocampus dentations - or "bumps" on the inferior surface of the hippocampus - and whether they hold functional significance. Empirical work on these features is beginning to emerge, but no study has yet been conducted in which their spatial positions are demarcated, and their putative role in individual differences in memory is based on a single small study. We gathered ultra-high resolution isotropic MTL scans from young-adult sample and performed such measurements. On the long axis, we found smaller and denser dentations moving towards the hippocampus posterior extent. Although other reports have distinguished the functional characteristics of anterior and posterior hippocampal dentations, we found hardly any were actually localized in the hippocampal head, with half of participants featuring no anterior dentations at all. We also observed more numerous dentations in the left hemisphere than right, and found this asymmetry tracked right-hand dominance. All dentations lay specifically within in the CA1 subfield, which was thicker at dentations - protruding below standard lower boundary of the hippocampus - as well as larger in participants with more dentations, suggesting dentations reflect CA1 growth rather than mere folding. Finally, we observed an association between dentations and visual source memory, but not recognition memory. The current report is the first to characterize the spatial properties of this intriguing neuroanatomical feature, which requires the direct spatial labeling of dentations. Further to better characterizing this intriguing neuroanatomical feature, we provide some confirmatory evidence for a link to episodic memory, although we found evidence for this link to be less overwhelming than initially reported.

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ten Hove, J., Poppenk, J.. 2020-02-10. Structural variation in hippocampal dentations among healthy young adults. https://doi.org/10.1101/2020.02.09.940726

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