Epidynamics characterize and navigate the map of seizure dynamics

Saggio, M.; Crisp, D.; Scott, J. M.; Karoly, P.; Kuhlmann, L.; Nakatani, M.; Murai, T.; Duempelmann, M.; Schulze-Bonhage, A.; Ikeda, A.; Cook, M.; Gliske, S. V.; Lin, J.; Bernard, C.; Jirsa, V.; Stacey, W. C.

doi:10.1101/2020.02.08.940072

bioRxiv · 10.1101/2020.02.08.940072

Epidynamics characterize and navigate the map of seizure dynamics

Saggio, M.·Crisp, D.·Scott, J. M.·Karoly, P.·Kuhlmann, L.·Nakatani, M.·Murai, T.·Duempelmann, M.·Schulze-Bonhage, A.·Ikeda, A.·Cook, M.·Gliske, S. V.·Lin, J.·Bernard, C.·Jirsa, V.·Stacey, W. C.

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Abstract

Seizures are a disruption of normal brain activity present across a vast range of species, diseases, and conditions. Here we introduce an organizing principle that leads to the first objective Taxonomy of Seizure Dynamics (TSD) based on bifurcation theory, and applied it to the analysis of EEG data. The "dynamotype" of a seizure is the part of its dynamic composition that defines its observable characteristics, including how it starts, evolves and terminates. Analyzing over 2000 focal-onset seizures recorded from 7 epilepsy centers on five continents, we find evidence of all 16 dynamotypes predicted in TSD. We demonstrate that patients dynamotypes evolve during their lifetime and display complex but systematic variations including hierarchy (certain dynamotypes are more common), non-bijectivity (a patient may display multiple dynamotypes) and pairing preference (multiple dynamotypes may occur during one seizure). TSD not only provides a way to stratify patients in complement to present practical classifications but also guides biophysically based mechanistic approaches and provides a language to describe the most critical features of seizure dynamics. Impact statementTaxonomy of Seizure Dynamics (TSD) provides a rigorous method for classifying and quantifying seizures and a principled framework for understanding seizure initiation and propagation.

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Saggio, M., Crisp, D., Scott, J. M., Karoly, P., Kuhlmann, L., Nakatani, M., Murai, T., Duempelmann, M., Schulze-Bonhage, A., Ikeda, A., Cook, M., Gliske, S. V., Lin, J., Bernard, C., Jirsa, V., Stacey, W. C.. 2020-02-09. Epidynamics characterize and navigate the map of seizure dynamics. https://doi.org/10.1101/2020.02.08.940072

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