Midbrain modulation of conditioned learning

Tan, K. R.; Rizzi, G.; Li, Z.; Hogrefe, N.

doi:10.1101/2020.02.07.936963

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bioRxiv · 10.1101/2020.02.07.936963

Midbrain modulation of conditioned learning

Tan, K. R.·Rizzi, G.·Li, Z.·Hogrefe, N.

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Abstract

The firing activity of striatal cholinergic interneurons (CINs) is a neural correlate of conditioned learning. However, its circuitry is not entirely described. Here we report that midbrain GABA and Glutamate neurons discriminate auditory cues and encode the association of a predictive stimulus with a footshock. Through their mono- and di-synaptic inputs via the thalamic-parafasicular sub-nucleus onto CINs, they contribute to processing fear learning.

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Tan, K. R., Rizzi, G., Li, Z., Hogrefe, N.. 2020-02-07. Midbrain modulation of conditioned learning. https://doi.org/10.1101/2020.02.07.936963

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