Non-invasive, Real-time Detection of Vascular Disorders in Mice using Bright SWIR-emitting Gold Nanoclusters and Monte Carlo Image Analysis

Yu, Z.; Musnier, B.; Henry, M.; Wegner, K. D.; Chovelon, B.; Desroches-Castan, A.; Fertin, A.; Resch-Genger, U.; Coll, J.-l.; Bailly, S.; Usson, Y.; Josserand, V.; Le Guevel, X.

doi:10.1101/2020.01.31.928382

bioRxiv · 10.1101/2020.01.31.928382

Non-invasive, Real-time Detection of Vascular Disorders in Mice using Bright SWIR-emitting Gold Nanoclusters and Monte Carlo Image Analysis

Yu, Z.·Musnier, B.·Henry, M.·Wegner, K. D.·Chovelon, B.·Desroches-Castan, A.·Fertin, A.·Resch-Genger, U.·Coll, J.-l.·Bailly, S.·Usson, Y.·Josserand, V.·Le Guevel, X.

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Abstract

We present here a new approach for non-invasive high resolution whole-body vascular imaging in depth by combining water-soluble and bright SWIR-emitting gold nanoclusters revealing an anisotropic surface charge with Monte Carlo image processing of the images. We applied and validated this approach to quantify vessel complexity in transgenic mice presenting vascular disorders.

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Yu, Z., Musnier, B., Henry, M., Wegner, K. D., Chovelon, B., Desroches-Castan, A., Fertin, A., Resch-Genger, U., Coll, J.-l., Bailly, S., Usson, Y., Josserand, V., Le Guevel, X.. 2020-02-02. Non-invasive, Real-time Detection of Vascular Disorders in Mice using Bright SWIR-emitting Gold Nanoclusters and Monte Carlo Image Analysis. https://doi.org/10.1101/2020.01.31.928382

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