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bioRxiv · 10.1101/2020.01.25.919423

Memory deficits following hippocampal versus parahippocampal damage double-dissociate according to both process and material type

Abstract

A central debate in the systems neuroscience of memory concerns whether different medial temporal lobe (MTL) structures support different processes or material-types in recognition memory. We tested a rare patient (Patient MH) with a perirhinal lesion that appeared to spare the hippocampus, using two recognition memory paradigms, each run separately with faces, scenes and words. Replicating reports of a previous case, Patient MH showed impaired familiarity and preserved recollection, relative to controls, with no evidence for any effect of material-type. Moreover, when compared with other amnesic patients, who had hippocampal lesions that appeared to spare the perirhinal cortex, Patient MH showed greater impairment on familiarity and less on recollection, forming a double dissociation. However, when replacing this traditional, binary categorization of patients with a parametric analysis that related memory performance to continuous measures of brain damage across all patients, we found a different pattern: while hippocampal damage predicted recollection, it was parahippocampal instead of perirhinal (or entorhinal) cortex volume that predicted familiarity. Furthermore, there was no evidence that these brain-behavior relationships were moderated by material-type, nor by laterality of damage. Thus, while our data provide the most compelling support yet for dual-process models of recognition memory, in which recollection and familiarity depend on different MTL structures, they suggest that familiarity depends more strongly upon the parahippocampal rather than perirhinal cortex. More generally, our study reinforces the need to go beyond single-case and group studies, and instead examine continuous brain-behavior relationships across larger patient groups.

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BibTeXRIS

Argyropoulos, G. P. D., Dell'Acqua, C., Butler, E., Loane, C., Roca-Fernandez, A., Almozel, A., Drummond, N., Lage-Martinez, C., Cooper, E., Henson, R. N., Butler, C. R.. 2020-01-25. Memory deficits following hippocampal versus parahippocampal damage double-dissociate according to both process and material type. https://doi.org/10.1101/2020.01.25.919423

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