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bioRxiv · 10.1101/2020.01.07.898056

Decoding the regulatory architecture of the maize leaf

Abstract

The transcription regulatory network underlying essential and complex functionalities inside a eukaryotic cell is defined by the combinatorial actions of transcription factors (TFs). However, TF binding studies in plants are too few in number to produce a general picture of this complex regulatory netowrk. Here, we used ChIP-seq to determine the binding profiles of 104 TF expressed in the maize leaf. With this large dataset, we could reconstruct a transcription regulatory network that covers over 77% of the expressed genes, and reveal its scale-free topology and functional modularity like a real-world network. We found that TF binding occurs in clusters covering [~]2% of the genome, and shows enrichment for sequence variations associated with eQTLs and GWAS hits of complex agronomic traits. Machine-learning analyses were used to identify TF sequence preferences, and showed that co-binding is key for TF specificity. The trained models were used to predict and compare the regulatory networks in other species and showed that the core network is evolutionarily conserved. This study provided an extensive description of the architecture, organizing principle and evolution of the transcription regulatory network inside the plant leaf.

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BibTeXRIS

Tu, X., Mejia Guerra, M. K., Franco, J. A. V., Tzeng, D., Chu, P.-Y., Dai, X., Li, P., Buckler, E. S., Zhong, S.. 2020-01-08. Decoding the regulatory architecture of the maize leaf. https://doi.org/10.1101/2020.01.07.898056

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