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bioRxiv · 10.1101/2019.12.27.889444

Validation of a Mathematical Model of Cancer Incorporating Spontaneous and Induced Evolution to Drug Resistance

Gevertz, J. L.·Greene, J. M.·Sontag, E. D.
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Abstract

This paper continues the study of a model which was introduced in earlier work by the authors to study spontaneous and induced evolution to drug resistance under chemotherapy. The model is fit to existing experimental data, and is then validated on additional data that had not been used when fitting. In addition, an optimal control problem is studied numerically.

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Gevertz, J. L., Greene, J. M., Sontag, E. D.. 2019-12-28. Validation of a Mathematical Model of Cancer Incorporating Spontaneous and Induced Evolution to Drug Resistance. https://doi.org/10.1101/2019.12.27.889444

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