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bioRxiv · 10.1101/2019.12.12.874826

Oligomerization of the antimalarial drug target PfATP4 is essential for parasite survival

Ramanathan, A. A.·Morrisey, J. M.·Daly, T. M.·Bergman, L. W.·Mather, M. W.·Vaidya, A. B.
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Abstract

Withdrawal StatementThe authors have withdrawn their manuscript owing to further investigations on PfATP4 that have revealed that the main conclusion of the preprint that PfATP4 forms oligomers is incorrect. Initial cryogenic electron microscopy observations showed a large detergent belt that surrounds monomers of PfATP4, which could have affected migration of the molecule on blue-native polyacrylamide gels. This gave an incorrect impression of the molecule to be in a dimeric or oligomeric state. Authors regret this error in interpreting the data. Therefore, the authors do not wish this work to be cited as reference for the project. If you have any questions, please contact the corresponding author.

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Ramanathan, A. A., Morrisey, J. M., Daly, T. M., Bergman, L. W., Mather, M. W., Vaidya, A. B.. 2019-12-13. Oligomerization of the antimalarial drug target PfATP4 is essential for parasite survival. https://doi.org/10.1101/2019.12.12.874826

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