Gradual progression from sensory to task-related processing in cerebral cortex

Abstract

Somewhere along the cortical hierarchy, behaviorally relevant information is distilled from raw sensory inputs. We examined how this transformation progresses along multiple levels of the hierarchy by comparing neural representations in visual, temporal, parietal, and frontal cortices in monkeys categorizing across three visual domains (shape, motion direction, color). Representations in visual areas MT and V4 were tightly linked to external sensory inputs. In contrast, lateral prefrontal cortex (PFC) largely represented the abstracted behavioral relevance of stimuli (task rule, motion category, color category). Intermediate-level areas--posterior inferotemporal (PIT), lateral intraparietal (LIP), and frontal eye fields (FEF)--exhibited mixed representations. While the distribution of sensory information across areas aligned well with classical functional divisions--MT carried stronger motion information, V4 and PIT carried stronger color and shape information--categorical abstraction did not, suggesting these areas may participate in different networks for stimulus-driven and cognitive functions. Paralleling these representational differences, the dimensionality of neural population activity decreased progressively from sensory to intermediate to frontal cortex. This shows how raw sensory representations are transformed into behaviorally relevant abstractions and suggests that the dimensionality of neural activity in higher cortical regions may be specific to their current task.\n\nSignificance statementThe earliest stages of processing in cerebral cortex reflect a relatively faithful copy of sensory inputs, but intelligent behavior requires abstracting behaviorally relevant concepts and categories. We examined how this transformation progresses through multiple levels of the cortical hierarchy by comparing neural representations in six cortical areas in monkeys categorizing across three visual domains. We found that categorical abstraction occurred in a gradual fashion across the cortical hierarchy and reached an apex in prefrontal cortex. Categorical coding did not respect classical models of large-scale cortical organization. The dimensionality of neural population activity was reduced in parallel with these representational changes. Our results shed light on how raw sensory inputs are transformed into behaviorally relevant abstractions.