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bioRxiv · 10.1101/194167

Genetic study links components of the autonomous nervous system to heart-rate profile during exercise

Verweij, N.·van de Vegte, Y. J.·van der Harst, P.
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Abstract

Heart rate (HR) response to exercise, as defined by HR-increase upon exercise and HR-recovery after exercise, is an important predictor of mortality and believed to be modulated by the autonomic nervous system. However, the mechanistic basis underlying inter-individual differences remains to be elucidated. To investigate this, we performed a large-scale genome wide analysis of HR-increase and HR-recovery in 58,818 individuals. A total of 25 significant independent SNPs in 23 loci (P<8.3x10-9) were associated with HR-increase or HR-recovery, and 36 candidate causal genes were prioritized that were enriched for pathways related to neuron biology. There was no evidence of a causal relationship with mortality or cardiovascular diseases, however, a nominal association with parental lifespan was observed (5.5x10-4) that requires further study. In conclusion, our findings provide new biological and clinical insight into the mechanistic under-pinning of HR response to exercise, underscoring the role of the autonomous nervous system in HR-recovery.\n\nABBREVIATIONS

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Verweij, N., van de Vegte, Y. J., van der Harst, P.. 2017-10-04. Genetic study links components of the autonomous nervous system to heart-rate profile during exercise. https://doi.org/10.1101/194167

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