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bioRxiv · 10.1101/187476

CA1 and CA3 pyramidal cell morphologies under Alzheimer’s disease Amyloid beta interaction

Rodrigues, Y. E.·da Silva Freitas, J.
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Abstract

Alzheimers disease (AD) is a fatal neurodegenerative disorder, which imposes a growing burden on society and health systems worldwide. Remarkable, computational models for AD are rare in comparison to epilepsy and other neuropathologies. Also, neuromorphologi-cal variability in the available models is usually neglected. Here, we evaluated geometrically detailed CA1 and CA3 pyramidal neurons from rats hippocampus and its firing probability face to Amyloid-{beta} (A{beta}), a pre-plaque soluble confirmation. Such comparison is invaluable since the hippocampus acts as a structural predictor of AD progression. A stimulation protocol designed to elicit a single spike is used to access neuronal vulnerability against the A{beta} oligomers. Our experiment shows that under the same conditions there is a firing facilitation for CA3 neurons in comparison to CA1.

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Rodrigues, Y. E., da Silva Freitas, J.. 2017-09-12. CA1 and CA3 pyramidal cell morphologies under Alzheimer’s disease Amyloid beta interaction. https://doi.org/10.1101/187476

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