An almost nearly optimal sequential testing approach to permutation-based association testing

Hecker, J.; Ruczinksi, I.; Coull, B.; Lange, C.

doi:10.1101/186361

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bioRxiv · 10.1101/186361

An almost nearly optimal sequential testing approach to permutation-based association testing

Hecker, J.·Ruczinksi, I.·Coull, B.·Lange, C.

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Abstract

The following technical report describes the technical details for the implementation of a sequential testing approach to permutation-based association testing in whole-genome sequencing studies. The sequential testing approach enables to control the probability of a type 1 and type 2 error at arbitrary small pre-specified levels and approaches the theoretical minimum of expected number of required permutations as these levels go to zero.

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Hecker, J., Ruczinksi, I., Coull, B., Lange, C.. 2017-09-11. An almost nearly optimal sequential testing approach to permutation-based association testing. https://doi.org/10.1101/186361

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