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bioRxiv · 10.1101/185165

Assessment of CD4 T Lymphocyte Cell Levels among Hepatitis B, C and E Viruses Negative Individuals in Ibadan, southwestern Nigeria

Adewumi, M. O.·Omoruyi, E. C.·Ifeora, I. M.·Bakarye, A. S.·Ogunwale, A. O.·Akere, A.·Faleye, T. O. C.·Adeniji, J. A.
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Abstract

The CD4 T lymphocytes play a key role in achieving a regulated effective immune response to foreign antigens. It is also a valuable parameter for assessing HIV disease progression. However, variations in CD4 T lymphocyte values due to diverse factors have been reported. We evaluated CD4 T lymphocytes among healthy community dwellers who tested negative for hepatitis B, hepatitis C and hepatitis E viruses and compared the results with the National Reference Values (NRVs). Four hundred consenting participants who fulfilled the criteria for enrolment were evaluated for CD4 T lymphocyte counts. Estimated mean CD4 T lymphocyte count of 1,183 (CD4 Range: 328-2680) cells/l of blood was recorded for the participants. Four (1.0%), 151 (37.8%), 157 (39.2%), 74 (18.5), and 14 (3.5) of the participants had CD4 T lymphocyte count ranged 352-500, 501-1,000, 1,001-1500, 1501-2,000, and >2,000 cells/l of blood, respectively. Differences in the estimated mean CD4 count between different age groups varied significantly (P=0.010). In this study, significantly higher CD4 T lymphocyte values were observed among the study population in comparison to the NRVs, and consequently we advise careful interpretation and use of extrapolated CD4 T lymphocyte values in the management of persons with diverse geographical background or health conditions.

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Adewumi, M. O., Omoruyi, E. C., Ifeora, I. M., Bakarye, A. S., Ogunwale, A. O., Akere, A., Faleye, T. O. C., Adeniji, J. A.. 2017-09-06. Assessment of CD4 T Lymphocyte Cell Levels among Hepatitis B, C and E Viruses Negative Individuals in Ibadan, southwestern Nigeria. https://doi.org/10.1101/185165

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