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bioRxiv · 10.1101/177188

A high-performance, inexpensive setup for simultaneous multi-site recording of electrophysiological signals and wide-field optical imaging of the mouse cortex

Abstract

Simultaneous recording of optical and electrophysiological signals from multiple cortical areas may provide crucial information to expand our understanding of cortical function. However, the insertion of multiple electrodes into the brain may compromise optical imaging by both restricting the field of view, and interfering with the approaches used to stabilize the specimen. Existing methods that combine electrophysiological recording and optical imaging in vivo implement either multiple surface electrodes or a single electrode for deeper recordings. To address such limitation, we built a microelectrode array (hyperdrive) compatible with wide-field imaging that allows insertion of up to 12 probes into a large brain area (8 mm diameter). The developed hyperdrive is comprised of a circle of individual microdrives where probes are positioned at an angle leaving a large brain area unobstructed for wide-field imaging. Multiple tetrodes and voltage-sensitive dye imaging (VSDI) were used for simultaneous registration of spontaneous and evoked cortical activity. The electrophysiological signals were used to extract local field potential (LFP) traces, multiunit and single-unit spiking activity. To demonstrate our approach, we compared LFP and VSD signals over multiple regions of the cortex and analyzed the relationship between single-unit and global cortical population activities. The study of the interactions between cortical activity at local and global scales, such as the one presented in this work, can help to expand our knowledge of brain function.

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BibTeXRIS

Bermudez Contreras, E. J., Chekhov, S., Tarnowsky, J., Sun, J., McNaughton, B. L., Mohajerani, M. H.. 2017-08-17. A high-performance, inexpensive setup for simultaneous multi-site recording of electrophysiological signals and wide-field optical imaging of the mouse cortex. https://doi.org/10.1101/177188

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