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bioRxiv · 10.1101/164525

Mechanosensing of Integrin α6 and EGFR Converges atCalpain 2

Schwartz, A. D.·Hall, C. L.·Barney, L. E.·Babbitt, C. C.·Peyton, S. R.
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Abstract

Introduction Introduction Materials and Methods Results Discussion Conclusions Author Contributions Conflict of Interest References Carcinoma progression is associated with deposition of ECM that stiffens the local microenvironment [1, 2]. This tissue stiffening results in deposition of additional matrix proteins, initiating a positive feedback loop between cells and the evolving stroma [3]. Cells sense and respond to the stiffness of their environment via RhoA GTPase activation, which feeds back to increase cell contractility via activation of myosin light chain kinase [4]. These ECM-driven changes in cytoskeletal tension regulate motility in a cell-type specific manner [5]. In vi ...

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Schwartz, A. D., Hall, C. L., Barney, L. E., Babbitt, C. C., Peyton, S. R.. 2017-07-17. Mechanosensing of Integrin α6 and EGFR Converges atCalpain 2. https://doi.org/10.1101/164525

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