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bioRxiv · 10.1101/154203

Fluid administration rate for uncontrolled intraabdominal hemorrhage in pigs

Yanala, U. R.·Johanning, J. M.·Pipinos, I. I.·High, R. R.·Larsen, G.·Velander, W. H.·Carlson, M.
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Abstract

BackgroundWe hypothesized that slow crystalloid resuscitation would improve blood loss and hemoglobin compared to a rapid resuscitation during uncontrolled hemorrhage.\n\nMethodsAnesthetized, splenectomized domestic swine underwent hepatic lobar hemitransection. Lactated Ringers was given at 150 or 20 mL/min IV (rapid vs. slow, respectively, N = 12 per group; limit of 100 mL/kg). Vital sign monitoring and serum testing was done for up to 180 min, followed by necropsy.\n\nResultsSurvival was 7 vs. 8 out of 12 subjects, rapid vs. slow respectively (p>0.05). The slow group had a less blood loss (1.6 vs. 2.7 L, respectively) and a higher final hemoglobin concentration (6.0 vs. 3.4 g/dL).\n\nConclusionsUsing a fixed volume of crystalloid resuscitation in this porcine model of uncontrolled intraabdominal hemorrhage, a slow IV infusion rate produced less blood loss and a higher hemoglobin level compared to rapid infusion.

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Yanala, U. R., Johanning, J. M., Pipinos, I. I., High, R. R., Larsen, G., Velander, W. H., Carlson, M.. 2017-06-23. Fluid administration rate for uncontrolled intraabdominal hemorrhage in pigs. https://doi.org/10.1101/154203

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