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bioRxiv · 10.1101/153007

Differential roles of sleep spindles and sleep slow oscillations in memory consolidation

Abstract

Sleep plays an important role in consolidation of recent memories. However, the mechanisms of consolidation remain poorly understood. In this study, using a realistic computational model of the thalamocortical network, we demonstrated that sleep spindles (the hallmark of N2 stage sleep) and slow oscillations (the hallmark of N3 stage sleep) both facilitate spike sequence replay as necessary for consolidation. When multiple memories were trained, the local nature of spike sequence replay during spindles allowed replay of the memories independently, while during slow oscillations replay of the weak memory was competing to the strong memory replay. This led to the weak memory extinction unless when sleep spindles (N2 sleep) preceded slow oscillations (N3 sleep), as observed during natural sleep. Our study presents a mechanistic explanation for the role of sleep rhythms in memory consolidation and proposes a testable hypothesis how the natural structure of sleep stages provides an optimal environment to consolidate memories.\n\nSignificant StatementNumerous studies suggest importance of NREM sleep rhythms - spindles and slow oscillations - in sleep related memory consolidation. However, synaptic mechanisms behind the role of these rhythms in memory and learning are still unknown. Our new study predicts that sleep replay - the neuronal substrate of memory consolidation - is organized within the sleep spindles and coordinated by the Down to Up state transitions of the slow oscillation. For multiple competing memories, slow oscillations facilitated only strongest memory replay, while sleep spindles allowed a consolidation of the multiple competing memories independently. Our study predicts how the basic structure of the natural sleep stages provides an optimal environment for consolidation of multiple memories.

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BibTeXRIS

Wei, Y., Krishnan, G. P., Komarov, M., Bazhenov, M.. 2017-06-21. Differential roles of sleep spindles and sleep slow oscillations in memory consolidation. https://doi.org/10.1101/153007

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