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bioRxiv · 10.1101/141515

Association Between A Functional Polymorphism rs10830963 In Melatonin Receptor 1B And Risk Of Gestational Diabetes Mellitus: An Updated Meta-Analysis

Yu, X.-y.·Wang, Q.-q.·Qin, L.-y.·Peng, L.-x.·Chen, Z.-m.·Qin, X.-m.·Wang, Y.-c.·Shi, Q.-f.·Yu, H.-p.
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Abstract

The melatonin receptor 1B (MTNR1B) as a candidate gene for gestational diabetes mellitus (GDM) on the basis of its association with T2DM, {beta}-cells function and fasting plasma glucose (FPG) level. Many studies have investigated the association between MTNR1B polymorphism rs10830963 C>G and GDM risk, but the conclusion is inconsistent. PubMed, Google Scholar and CNKI databases were searched to identify eligible studies. Pooled OR with corresponding 95% CI was used to estimate the strength of the association between rs10830963 and GDM risk using a fixed- or random-effect model. 12 eligible studies with a number of 4,782 GDM patients and 5,605 controls were included in this meta-analysis. Results indicated that the variant G allele of rs10830963 polymorphism was significantly associated with an increased risk of GDM (CG vs. CC: OR=1.23, 95% CI = 1.12-1.34, Pheterogeneity = 0.23; GG vs. CC: OR=1.74, 95% CI =1.41-2.15, Pheterogeneity = 0.002). In the stratified analysis by ethnicity, similar results were found in Asians (CG vs. CC: OR=1.15, 95% CI = 1.04-1.28, Pheterogeneity = 0.74; GG VS. CC: OR=1.48, 95% CI =1.23-1.78, Pheterogeneity = 0.08) and in Caucasians (CG vs. CC: OR=1.49, 95% CI =1.25-1.77, Pheterogeneity = 0.28; GG vs. CC: OR=2.68, 95% CI =2.03-3.54, Pheterogeneity = 0.58).

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Yu, X.-y., Wang, Q.-q., Qin, L.-y., Peng, L.-x., Chen, Z.-m., Qin, X.-m., Wang, Y.-c., Shi, Q.-f., Yu, H.-p.. 2017-05-25. Association Between A Functional Polymorphism rs10830963 In Melatonin Receptor 1B And Risk Of Gestational Diabetes Mellitus: An Updated Meta-Analysis. https://doi.org/10.1101/141515

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