Cancer Genome Interpreter Annotates The Biological And Clinical Relevance Of Tumor Alterations

Tamborero, D.; Rubio-Perez, C.; Deu-Pons, J.; Schroeder, M. P.; Vivancos, A.; Rovira, A.; Tusquets, I.; Albanell, J.; Rodon, J.; Tabernero, J.; de Torres, C.; Dienstmann, R.; Gonzalez-Perez, A.; Lopez-Bigas, N.

doi:10.1101/140475

bioRxiv · 10.1101/140475

Cancer Genome Interpreter Annotates The Biological And Clinical Relevance Of Tumor Alterations

Tamborero, D.·Rubio-Perez, C.·Deu-Pons, J.·Schroeder, M. P.·Vivancos, A.·Rovira, A.·Tusquets, I.·Albanell, J.·Rodon, J.·Tabernero, J.·de Torres, C.·Dienstmann, R.·Gonzalez-Perez, A.·Lopez-Bigas, N.

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Abstract

While tumor genome sequencing has become widely available in clinical and research settings, the interpretation of tumor somatic variants remains an important bottleneck. Most of the alterations observed in tumors, including those in well-known cancer genes, are of uncertain significance. Moreover, the information on tumor genomic alterations shaping the response to existing therapies is fragmented across the literature and several specialized resources. Here we present the Cancer Genome Interpreter (http://www.cancergenomeinterpreter.org), an open access tool that we have implemented to annotate genomic alterations and interpret their possible role in tumorigenesis and in the response to anti-cancer therapies.

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Tamborero, D., Rubio-Perez, C., Deu-Pons, J., Schroeder, M. P., Vivancos, A., Rovira, A., Tusquets, I., Albanell, J., Rodon, J., Tabernero, J., de Torres, C., Dienstmann, R., Gonzalez-Perez, A., Lopez-Bigas, N.. 2017-05-20. Cancer Genome Interpreter Annotates The Biological And Clinical Relevance Of Tumor Alterations. https://doi.org/10.1101/140475

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