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bioRxiv · 10.1101/116194

Inferring Within-Host Bottleneck Size: A Bayesian Approach

Dybowski, R.·Restif, O.·Price, D. J.·Mastroeni, P.
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Abstract

A number of approaches exist for bottleneck-size estimation with respect to within-host bacterial infections; however, some are more appropriate than others under certain circumstances. A Bayesian comparison of several approaches is made in terms of the availability of isogenic multitype bacteria (e.g., WITS), knowledge of post-bottleneck dynamics, and the suitability of dilution with monotype bacteria. The results are summarised by a guiding flowchart.\n\nA sampling approach to bottleneck-size estimation is also introduced.

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Dybowski, R., Restif, O., Price, D. J., Mastroeni, P.. 2017-03-13. Inferring Within-Host Bottleneck Size: A Bayesian Approach. https://doi.org/10.1101/116194

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