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bioRxiv · 10.1101/108282

Resting-state network dysfunction in Alzheimer’s disease: a systematic review and meta-analysis

Badhwar, A.·Tam, A.·Dansereau, C.·Orban, P.·Hoffstaedter, F.·Bellec, P.
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Abstract

INTRODUCTIONWe performed a systematic review and meta-analysis of the Alzheimers disease (AD) literature to examine consistency of functional connectivity alterations in AD dementia and mild cognitive impairment (MCI), using resting-state functional magnetic resonance imaging (rsfMRI).\n\nMETHODSStudies were screened using a standardized procedure. Multiresolution statistics were performed to assess the spatial consistency of findings across studies.\n\nRESULTSThirty-four studies were included (1,363 participants, average 40 per study). Consistent alterations in connectivity were found in the default-mode, salience and limbic networks in patients with AD dementia, MCI, or in both groups. We also identified a bias in the literature towards specific examination of the default-mode network.\n\nDISCUSSIONConvergent evidence across the literature supports the use of resting-state connectivity as a biomarker of AD. The locations of consistent alterations suggest that metabolically expensive hub regions in the brain might be an early target of AD.

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Badhwar, A., Tam, A., Dansereau, C., Orban, P., Hoffstaedter, F., Bellec, P.. 2017-02-14. Resting-state network dysfunction in Alzheimer’s disease: a systematic review and meta-analysis. https://doi.org/10.1101/108282

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