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bioRxiv · 10.1101/101782

Cognitive task information is transferred between brain regions via resting-state network topology

Ito, T.·Kulkarni, K. R.·Schultz, D. H.·Mill, R. D.·Chen, R. H.·Solomyak, L. I.·Cole, M. W.
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Abstract

Resting-state network connectivity has been associated with a variety of cognitive abilities, yet it remains unclear how these connectivity properties might contribute to the neurocognitive computations underlying these abilities. We developed a new approach - information transfer mapping - to test the hypothesis that resting-state functional network topology describes the computational mappings between brain regions that carry cognitive task information. Here we report that the transfer of diverse, task-rule information in distributed brain regions can be predicted based on estimated activity flow through resting-state network connections. Further, we find that these task-rule information transfers are coordinated by global hub regions within cognitive control networks. Activity flow over resting-state connections thus provides a large-scale network mechanism for cognitive task information transfer and global information coordination in the human brain, demonstrating the cognitive relevance of resting-state network topology.

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Ito, T., Kulkarni, K. R., Schultz, D. H., Mill, R. D., Chen, R. H., Solomyak, L. I., Cole, M. W.. 2017-01-19. Cognitive task information is transferred between brain regions via resting-state network topology. https://doi.org/10.1101/101782

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