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bioRxiv · 10.1101/076554

Reading positional codes with fMRI: Problems and solutions

Kristjan Kalm·Dennis Norris
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Abstract

Neural mechanisms which bind items into sequences have been investigated in a large body of research in animal neurophysiology and human neuroimaging. However, a major problem in interpreting this data arises from a fact that several unrelated processes, such as memory load, sensory adaptation, and reward expectation, also change in a consistent manner as the sequence unfolds. In this paper we show that the problem of extracting neural data about the structure of a sequence is especially acute for fMRI, which is almost exclusively the modality used in human experiments. We show that such fMRI results must be treated with caution and in many cases the assumed neural representation might actually reflect unrelated processes.

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Kristjan Kalm, Dennis Norris. 2016-09-21. Reading positional codes with fMRI: Problems and solutions. https://doi.org/10.1101/076554

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