CIViC: A knowledgebase for expert-crowdsourcing the clinical interpretation of variants in cancer.

Malachi Griffith; Nicholas C Spies; Kilannin Krysiak; Adam C Coffman; Joshua F McMichael; Benjamin J Ainscough; Damian T Rieke; Arpad M Danos; Lynzey Kujan; Cody A Ramirez; Alex H Wagner; Zachary L Skidmore; Connor J Liu; Martin R Jones; Rachel L Bilski; Robert Lesurf; Erica K Barnell; Nakul M Shah; Melika Bonakdar; Lee Trani; Matthew Matlock; Avinash Ramu; Katie M Campbell; Gregory C Spies; Aaron P Graubert; Karthik Gangavarapu; James M Eldred; David E Larson; Jason R Walker; Benjamin M Good; Chunlei Wu; Andrew I Su; Rodrigo Dienstmann; Steven JM Jones; Ron Bose; David H Spencer; Lukas D Wartman; Richard K Wilson; Elaine R Mardis

doi:10.1101/072892

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bioRxiv · 10.1101/072892

CIViC: A knowledgebase for expert-crowdsourcing the clinical interpretation of variants in cancer.

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Abstract

CIViC is an expert crowdsourced knowledgebase for Clinical Interpretation of Variants in Cancer (www.civicdb.org) describing the therapeutic, prognostic, and diagnostic relevance of inherited and somatic variants of all types. CIViC is committed to open source code, open access content, public application programming interfaces (APIs), and provenance of supporting evidence to allow for the transparent creation of current and accurate variant interpretations for use in cancer precision medicine.

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Malachi Griffith, Nicholas C Spies, Kilannin Krysiak, Adam C Coffman, Joshua F McMichael, Benjamin J Ainscough, Damian T Rieke, Arpad M Danos, Lynzey Kujan, Cody A Ramirez, Alex H Wagner, Zachary L Skidmore, Connor J Liu, Martin R Jones, Rachel L Bilski, Robert Lesurf, Erica K Barnell, Nakul M Shah, Melika Bonakdar, Lee Trani, Matthew Matlock, Avinash Ramu, Katie M Campbell, Gregory C Spies, Aaron P Graubert, Karthik Gangavarapu, James M Eldred, David E Larson, Jason R Walker, Benjamin M Good, Chunlei Wu, Andrew I Su, Rodrigo Dienstmann, Steven JM Jones, Ron Bose, David H Spencer, Lukas D Wartman, Richard K Wilson, Elaine R Mardis. 2016-09-01. CIViC: A knowledgebase for expert-crowdsourcing the clinical interpretation of variants in cancer.. https://doi.org/10.1101/072892

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