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bioRxiv · 10.1101/060806

Varapp: A reactive web-application for variants filtering

Julien Delafontaine·Alexandre Masselot·Robin Liechti·Dmitry Kuznetsov·Ioannis Xenarios·Sylvain Pradervand
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Abstract

Summary: Varapp is an open-source web application to filter variants from large sets of exome data stored in a relational database. Varapp offers a reactive graphical user interface, very fast data pro-cessing, security and facility to save, reproduce and shareresults. Typically, a few seconds suffice to apply non-trivial filters to a set of half a million variants and extract a handful of potential clinically relevant targets. Varapp implements different scenarios for Mendelian diseases (dominant, recessive, de novo, X-linked, andcompound heterozygous), and allows searching for variants in genes or chro-mosomal regions of interest.\n\nAvailability: The application is made of a Javascript front-end and a Python back-end. Its source code is hosted at https://github.com/varapp. A demo version isavailable at https://varapp-demo.vital-it.ch. The full documentation can be found at https://varapp-demo.vital-it.ch/docs.\n\nContact: sylvain.pradervand@chuv.ch

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Julien Delafontaine, Alexandre Masselot, Robin Liechti, Dmitry Kuznetsov, Ioannis Xenarios, Sylvain Pradervand. 2016-06-28. Varapp: A reactive web-application for variants filtering. https://doi.org/10.1101/060806

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