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bioRxiv · 10.1101/058867

FPD: A comprehensive phosphorylation database in fungi

Youhuang Bai·Bin Chen·Yincong Zhou·Silin Ren·Qin Xu·Ming Chen·Shihua Wang
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Abstract

Protein phosphorylation, one of the most classic post-translational modification, plays a critical role in the diverse cellular processes including cell cycle, growth and signal transduction pathways. However, the available information of phosphorylation in fungi is limited. Here we provided a Fungi Phosphorylation Database (FPD) that comprises high-confidence in vivo phosphosites identified by MS-based proteomics in various fungal species. This comprehensive phosphorylation database contains 62,272 non-redundant phosphorylation sites in 11,222 proteins across eight organisms, including Aspergillus flavus, Aspergillus nidulans, Fusarium graminearum, Magnaporthe oryzae, Neurospora crassa, Saccharomyces cerevisiae, Schizosaccharomyces pombe and Cryptococcus neoformans. A fungi-specific phosphothreonine motif and several conserved phosphorylation motif were discovered by comparatively analyzing the pattern of phosphorylation sites in fungi, plants and animals.\n\nDatabase URL: http://bis.zju.edu.cn/FPD/index.php

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Youhuang Bai, Bin Chen, Yincong Zhou, Silin Ren, Qin Xu, Ming Chen, Shihua Wang. 2016-06-14. FPD: A comprehensive phosphorylation database in fungi. https://doi.org/10.1101/058867

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