Enhancing synergy of CAR T cell therapy and oncolytic virus therapy for pancreatic cancer.

Rachel Walker; Pedro E Navas; Samuel H Friedman; Simona Galliani; Aleksandra Karolak; Fiona MacFarlane; Robert Noble; Jan Poleszczuk; Shonagh Russell; Katarzyna A Rejniak; Amir Shahmoradi; Frederik Ziebell; Jason Brayer; Daniel Abate-Daga; Heiko Enderling

doi:10.1101/055988

bioRxiv · 10.1101/055988

Enhancing synergy of CAR T cell therapy and oncolytic virus therapy for pancreatic cancer.

Rachel Walker·Pedro E Navas·Samuel H Friedman·Simona Galliani·Aleksandra Karolak·Fiona MacFarlane·Robert Noble·Jan Poleszczuk·Shonagh Russell·Katarzyna A Rejniak·Amir Shahmoradi·Frederik Ziebell·Jason Brayer·Daniel Abate-Daga·Heiko Enderling

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Abstract

The poor immunogenicity of pancreatic tumors makes them particularly difficult to treat. Standard chemotherapies and single agent immunotherapies have had notoriously little success in this arena. Oncolytic virus therapy has the potential to enhance the penetration of immunotherapeutically-delivered CAR T cells into the tumor and improve treatment outcomes. We evaluate this potential by combining two different mathematical approaches: an ordinary differential equation model to simulate population level tumor response to cytotoxic activity of T cells, coupled with an agent-based model to simulate the enhancement of CAR T cell penetration by oncolytic virus therapy.

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Rachel Walker, Pedro E Navas, Samuel H Friedman, Simona Galliani, Aleksandra Karolak, Fiona MacFarlane, Robert Noble, Jan Poleszczuk, Shonagh Russell, Katarzyna A Rejniak, Amir Shahmoradi, Frederik Ziebell, Jason Brayer, Daniel Abate-Daga, Heiko Enderling. 2016-05-30. Enhancing synergy of CAR T cell therapy and oncolytic virus therapy for pancreatic cancer.. https://doi.org/10.1101/055988

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