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bioRxiv · 10.1101/052340

A Zika virus-associated microcephaly case with background exposure to STORCH agents

Mauro M Hanaoka·Alexandre Fligelman Kanas·Carla Torres Braconi·Erica Araujo Mendes·Robert Andreata Santos·Luis Carlos de Souza Ferreira·Marielton dos Passos Cunha·Patricia Beltrao-Braga·Joao Leonardo Mendonca Dias·Carolina Manganeli Polonio·David Anibal Garrido Andrade·Carla Longo de Freitas·Cristiano Rossato·Wesley Nogueira Brandao·Jean Pierre Schatzmann Peron·Antonio Gomes Amorim Filho·Joelma Queiroz Andrade·Rossana Pulcineli Vieira Francisco·Fernando Kok·Lisa Suzuki·Claudia da Costa Leite·Leandro Tavares Lucato·Amadou Alpha Sall·Paolo Marinho de Andrade Zanotto
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Abstract

We present a case of microcephaly associated with Zika virus (ZIKV) in a chronological, multimodal imaging approach, illustrating the hallmarks of this disease on intrauterine morphological ultrasound, transfontanelar ultrasound, computed tomography (CT) and magnetic resonance imaging (MRI). We also determined the serological e immunological status of the mother and newborn. Noticeably, there was evidence for maternal infection by ZIKV, cytomegalovirus (CMV), herpes simplex virus (HSV), dengue virus (DENV) and Toxoplasma gondii, which indicates a possible role of previous exposures to STORCH agents and possibly comorbidities in the severe fetal congenital manifestation.\n\nAuthor SummaryZika virus (ZIKV) is an emerging mosquito-borne arbovirus causing dengue-like symptoms. In humans the illness is characterized by malaise and cutaneous rash and absent or short-termed fever. Recently, the Brazilian Ministry of Health reported an outbreak of microcephaly in Brazil as a delayed effect of the 2014-2015 outbreak of ZIKV in the Northeast of Brazil. A 20-fold increase in the notifications of newborns with microcephaly was documented during the second semester of 2015. This increase was almost immediately found to be associated with ZIKV infections, both in Brazil and, retrospectively, in French Polynesia. Herein we report a case of microcephaly associated with ZIKV and we also present evidence of other maternal infections. Our results indicated that, both mother and microcephaly infant had immunologic status compatible with previous exposure (in the mother) by STORCH agents. These indicate a possible role of previous exposures and possibly comorbidities in the severe fetal congenital manifestation. {square}

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Mauro M Hanaoka, Alexandre Fligelman Kanas, Carla Torres Braconi, Erica Araujo Mendes, Robert Andreata Santos, Luis Carlos de Souza Ferreira, Marielton dos Passos Cunha, Patricia Beltrao-Braga, Joao Leonardo Mendonca Dias, Carolina Manganeli Polonio, David Anibal Garrido Andrade, Carla Longo de Freitas, Cristiano Rossato, Wesley Nogueira Brandao, Jean Pierre Schatzmann Peron, Antonio Gomes Amorim Filho, Joelma Queiroz Andrade, Rossana Pulcineli Vieira Francisco, Fernando Kok, Lisa Suzuki, Claudia da Costa Leite, Leandro Tavares Lucato, Amadou Alpha Sall, Paolo Marinho de Andrade Zanotto. 2016-05-10. A Zika virus-associated microcephaly case with background exposure to STORCH agents. https://doi.org/10.1101/052340

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