Using Ordinary Differential Equations to Explore Cancer-Immune Dynamics and Tumor Dormancy

Kathleen Wilkie; Philip Hahnfeldt; Lynn Hlatky

doi:10.1101/049874

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bioRxiv · 10.1101/049874

Using Ordinary Differential Equations to Explore Cancer-Immune Dynamics and Tumor Dormancy

Kathleen Wilkie·Philip Hahnfeldt·Lynn Hlatky

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Abstract

Cancer is not solely a disease of the genome, but is a systemic disease that affects the host on many functional levels, including, and perhaps most notably, the function of the immune response, resulting in both tumor-promoting inflammation and tumor-inhibiting cytotoxic action. The dichotomous actions of the immune response induce significant variations in tumor growth dynamics that mathematical modeling can help to understand. Here we present a general method using ordinary differential equations (ODEs) to model and analyze cancer-immune interactions, and in particular, immune-induced tumor dormancy.

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Kathleen Wilkie, Philip Hahnfeldt, Lynn Hlatky. 2016-04-22. Using Ordinary Differential Equations to Explore Cancer-Immune Dynamics and Tumor Dormancy. https://doi.org/10.1101/049874

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