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bioRxiv · 10.1101/049288

Impact of knowledge accumulation on pathway enrichment analysis

Lina Wadi·Mona Meyer·Joel Weiser·Lincoln D Stein·Juri Reimand
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Abstract

Pathway-based interpretation of gene lists is a staple of genome analysis. It depends on frequently updated gene annotation databases. We analyzed the evolution of gene annotations over the past seven years and found that the vocabulary of pathways and processes has doubled. This strongly impacts practical analysis of genes: 80% of publications we surveyed in 2015 used outdated software that only captured 20% of pathway enrichments apparent in current annotations.

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Lina Wadi, Mona Meyer, Joel Weiser, Lincoln D Stein, Juri Reimand. 2016-04-19. Impact of knowledge accumulation on pathway enrichment analysis. https://doi.org/10.1101/049288

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