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bioRxiv · 10.1101/037341

Analysis of Two-State Folding Using Parabolic Approximation II: Temperature-Dependence

Robert S Sade
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Abstract

Equations that govern the temperature-dependence of the rate constants, Gibbs energies, enthalpies, entropies and heat capacities of activation for folding and unfolding of spontaneously-folding fixed two-state systems have been derived using a procedure that treats the denatured and the native conformers as being confined to harmonic Gibbs energy wells. The notion that a two-state system is physically defined only for a set temperature range is introduced. The implications of this novel treatment for protein folding are discussed.

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Robert S Sade. 2016-01-20. Analysis of Two-State Folding Using Parabolic Approximation II: Temperature-Dependence. https://doi.org/10.1101/037341

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