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bioRxiv · 10.1101/034439

The Drosophila Neurogenin, Tap, controls axonal growth through the Wnt adaptor protein Dishevelled

Liqun Yuan·Shu Hu·Zeynep Okray·Xi Ren·Natalie De Geest·Annelies Claeys·Jiekun Yan·Eric Bellefroid·Bassem Hassan·Xiao-Jiang Quan
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Abstract

The Neurogenin (Ngn) transcription factors control early neurogenesis and neurite outgrowth in mammalian cortex. In contrast to their proneural activity, their function in neurite growth is poorly understood. Drosophila has a single predicted Ngn homologue called Tap, whose function is completely unknown. Here we show that Tap is not a proneural protein in Drosophila but is required for proper axonal growth and guidance of neurons of the mushroom body (MB), a neuropile required for associative learning and memory. Genetic and expression analyses suggest that Tap inhibits excessive axonal growth by fine regulation of the levels of the Wnt signaling adaptor protein, Dishevelled.\n\nSummaryThe Drosophila Neurogenin homologue, Target of Pox neuro (Tap), prevents axonal overgrowth by regulating the Wnt Planar Cell Polarity pathway adaptor protein Dishevelled.

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Liqun Yuan, Shu Hu, Zeynep Okray, Xi Ren, Natalie De Geest, Annelies Claeys, Jiekun Yan, Eric Bellefroid, Bassem Hassan, Xiao-Jiang Quan. 2015-12-15. The Drosophila Neurogenin, Tap, controls axonal growth through the Wnt adaptor protein Dishevelled. https://doi.org/10.1101/034439

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