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bioRxiv · 10.1101/032219

XMRF: An R package to Fit Markov Networks to High-Throughput Genetics Data

Ying-Wooi Wan·Genevera I. Allen·Yulia Baker·Eunho Yang·Pradeep Ravikumar·Zhandong Liu
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Abstract

MotivationTechnological advances in medicine have led to a rapid proliferation of high-throughput \"omics\" data. Tools to mine this data and discover disrupted disease networks are needed as they hold the key to understanding complicated interactions between genes, mutations and aberrations, and epi-genetic markers.\n\nResultsWe developed an R software package, XMRF, that can be used to fit Markov Networks to various types of high-throughput genomics data. Encoding the models and estimation techniques of the recently proposed exponential family Markov Random Fields (Yang et al., 2012), our software can be used to learn genetic networks from RNA-sequencing data (counts via Poisson graphical models), mutation and copy number variation data (categorical via Ising models), and methylation data (continuous via Gaussian graphical models).\n\nAvailabilityXMRF is available from the CRAN Project and Github at: https://github.com/zhandong/XMRF

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Ying-Wooi Wan, Genevera I. Allen, Yulia Baker, Eunho Yang, Pradeep Ravikumar, Zhandong Liu. 2015-11-18. XMRF: An R package to Fit Markov Networks to High-Throughput Genetics Data. https://doi.org/10.1101/032219

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