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bioRxiv · 10.1101/011221

WASP: allele-specific software for robust discovery of molecular quantitative trait loci

Bryce van de Geijn·Graham McVicker·Yoav Gilad·Jonathan Pritchard
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Abstract

Allele-specific sequencing reads provide a powerful signal for identifying molecular quantitative trait loci (QTLs), however they are challenging to analyze and prone to technical artefacts. Here we describe WASP, a suite of tools for unbiased allele-specific read mapping and discovery of molecular QTLs. Using simulated reads, RNA-seq reads and ChIP-seq reads, we demonstrate that our approach has a low error rate and is far more powerful than existing QTL mapping approaches.

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Bryce van de Geijn, Graham McVicker, Yoav Gilad, Jonathan Pritchard. 2014-11-07. WASP: allele-specific software for robust discovery of molecular quantitative trait loci. https://doi.org/10.1101/011221

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