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bioRxiv · 10.1101/010686

SomaticSignatures: Inferring Mutational Signatures from Single Nucleotide Variants

Julian S. Gehring·Bernd Fischer·Michael Lawrence·Wolfgang Huber
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Abstract

Mutational signatures are patterns in the occurrence of somatic single nucleotide variants (SNVs) that can reflect underlying mutational processes. The SomaticSignatures package provides flexible, interoperable, and easy-to-use tools that identify such signatures in cancer sequencing studies. It facilitates large-scale, cross-dataset estimation of mutational signatures, implements existing methods for pattern decomposition, supports extension through user-defined methods and integrates with Bioconductor workflows.\n\nThe R package SomaticSignatures is available as part of the Bioconductor project (R Core Team, 2014; Gentleman et al., 2004). Its documentation provides additional details on the methodology and demonstrates applications to biological datasets.

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Julian S. Gehring, Bernd Fischer, Michael Lawrence, Wolfgang Huber. 2014-10-24. SomaticSignatures: Inferring Mutational Signatures from Single Nucleotide Variants. https://doi.org/10.1101/010686

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