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bioRxiv · 10.1101/002667

The immunologic V-gene repertoire in mammals

David N Olivieri·Bernardo von Haeften·Christian Sánchez-Espinel·Francisco Gambón-Deza
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Abstract

From recent whole genome shotgun data of 48 mammalian species, we have used our software VgenExtractor to obtain the functional V-gene sequence repertoire in order to conduct comparative phylogenetic studies. These studies reveal a large variation in the number of V-genes across mammalian species, ranging from a mere 36 V-genes in dolphins to nearly 600 V-genes in rats. Monotremes and marsupials are the only mammals possessing an additional locus, the TRMV, apart from the seven common loci found in mammals. Also, we show evidence for the loss of the light chain loci, specifically the V{kappa} chain in one microbat, and the V{lambda} chain in one rodent species. Finally, we suggest different features related to the evolution of immunoglobulin and T cell receptor loci, where frequent sequence duplications are seen in the former, while preserved and undiversified lineages are observed in the latter. All the V-gene sequences described in this study are available in the public database repository vgenerepertoire.org.

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David N Olivieri, Bernardo von Haeften, Christian Sánchez-Espinel, Francisco Gambón-Deza. 2014-02-13. The immunologic V-gene repertoire in mammals. https://doi.org/10.1101/002667

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