TY - RPRT TI - Isosteric Engineering of Enzymes: Overcoming Activity-Stability Trade-offs by Site-Selective CH -> N Substitutions AU - Abdelkader, E. H. AU - Qianzhu, H. AU - Otting, G. AU - Huber, T. PY - 2026 DO - 10.64898/2026.02.24.707619 UR - https://www.biorxiv.org/content/10.64898/2026.02.24.707619v1 ID - 10.64898/2026.02.24.707619 ER -