Biology subjects

York, S.

Publications and source records attributed to York, S..

3 recordsLinked to original sources

bioRxiv2025

Association Between Vaginal Community States and Preeclampsia Status in Pregnant Individuals

Preeclampsia (PE) is a severe pregnancy complication affecting 3-8% of pregnancies. Recent evidence suggests the vaginal microbiome may influence PE risk. To investigate this, we reanalyzed publicly available 16S rRNA sequencing data (PRJNA798597) from vaginal samples of pregnant women with (n=10) and without PE (n=10) and assigned vaginal community state types which were previously uncharacterized. Overall microbial diversity did not differ significantly between groups; however, subtype differences in Lactobacillus spp. were observed. D-lactic acid-producing vaginal community state types were less common in PE, suggesting potential value for microbiome-based risk assessment.

microbiology↗

bioRxiv2025

No Distinct Gut Microbiome Signature in Alzheimer's Disease: A Reanalysis with Modern Tools

Alzheimers Disease (AD) is a neurodegenerative disorder that affects memory, cognition, and behavior. This study reanalyzes a publicly available 16S rRNA sequencing dataset (PRJNA554111) of fecal samples from 43 AD patients and 43 age-and-sex-matched controls to assess differences in microbial composition between the groups. We outlined the relative abundances of major phyla, and identified 137 ASVs across five phyla that were differentially abundant (padj<0.05). We found no distinct pattern of microbial composition distinguishing AD from controls, contrary to the original finding of disease-specific signatures.

microbiology↗

bioRxiv2025

Gut Microbiota Shifts with Lifetime Duration of Oral Contraception Use

To investigate the effects of lifetime duration of oral contraceptive (OC) use, we reanalyzed publicly available 16S rRNA sequencing data from fecal samples of OC users and non-users collected at different timepoints in the menstrual cycle. We profiled the microbial composition of subjects and identified 32 significantly differentially abundant Amplicon Sequence Variants (padj<0.05) with increasing lifetime use duration including 16 ASVs belonging to class Clostidia that decreased with longer OC use. Some Clostridia species are known to recycle estrogen; lifetime duration of OC exposure could thus influence womens health through gut microbiome composition and hormone regulation.

microbiology↗