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West, A. M.

Publications and source records attributed to West, A. M..

3 recordsLinked to original sources

Perceiving latent dynamics: Innate and coachable visual estimation of limb damping

Humans are remarkably adept at extracting latent dynamic information from purely visual cues. Prior work shows that people can innately estimate differences in limb stiffness using solely their visual observation of movement, which suggests that components of mechanical impedance may be embedded within humans internal predictive models of movement. We tested whether humans can similarly perceive damping, a force-velocity relationship, and whether targeted coaching can enhance this visual ability. Specifically, 30 participants observed abstract two-link arm simulations with systematically varied elbow damping and rated their perceived level of damping for several trials. Participants completed two sessions separated by one of three brief coaching interventions: (1) no coaching, (2) coaching to attend to hand velocity, or (3) coaching to attend to elbow-angle velocity. Results reveal that (1) humans can innately perceive changes in arm damping using solely their visual observation of motion and (2) coaching further improved performance, with the elbow-angle coaching group showing a significantly greater increase in rating accuracy compared to the other two groups. This work extends our understanding of how action-perception coupling supports inference of mechanical impedance. Moreover, we demonstrated that perceptual strategies for estimating damping are malleable and can be systematically improved through coaching. We not only identified the visual cues observers relied on but also guided them toward more classifiable features, effectively strengthening their perceptual models of limb dynamics. Author summaryHumans are remarkably adept at understanding an objects latent dynamic properties simply by watching it move, even when the underlying forces are unseen. In this paper, we demonstrated that people can notice differences in how "damped" a moving limb is using vision alone. Moreover, we found that brief coaching helped participants focus on the most informative features, significantly improving their ability to differentiate the damping levels. These results demonstrate how people can visually infer aspects of movement that are normally thought to require physical interaction, offering insight into how the motor system links action and perception. They also show that strategies can be shaped and improved, supporting real-world healthcare applications. In stroke rehabilitation, physical therapists physically assess the resistance of a patients limb, so better guidance on the most relevant visual cues can help clinicians learn faster and even provide care remotely. In robot-assisted surgery, surgeons operate a console to perform procedures with limited or no force feedback, so they must estimate tissue dynamics properties largely from visual observation. Understanding how people visually estimate these dynamics can inform training for more precise surgical decisions. Overall, our findings clarify how humans interpret movement dynamics and how coaching can support more consistent and accurate perceptual decisions.

neuroscience↗

Synaptogyrin-3 Prevents Cocaine Addiction and Dopamine Deficits

Synaptogyrin-3, a functionally obscure synaptic vesicle protein, interacts with vesicular monoamine and dopamine transporters, bringing together dopamine release and reuptake sites. Synaptogyrin-3 was reduced by chronic cocaine exposure in both humans and rats, and synaptogyrin-3 levels inversely correlated with motivation to take cocaine in rats. Synaptogyrin-3 overexpression in dopamine neurons reduced cocaine self-administration, decreased anxiety-like behavior, and enhanced cognitive flexibility. Overexpression also enhanced nucleus accumbens dopamine signaling and prevented cocaine-induced deficits, suggesting a putative therapeutic role for synaptogyrin-3 in cocaine use disorder.

neuroscience↗

De Coordinatione Motus Humani: The Synergy Expansion Hypothesis

The search for an answer to Bernsteins degrees of freedom problem has propelled a large portion of research studies in human motor control over the past six decades. Different theories have been developed to explain how humans might use their incredibly complex neuro-musculo-skeletal system with astonishing ease. Among these theories, motor synergies appeared as one possible explanation. In this work, the authors investigate the nature and role of synergies and propose a new theoretical framework, namely the "expansion hypothesis", to answer Bernsteins problem. The expansion hypothesis is articulated in three propositions: mechanical, developmental, and behavioral. Each proposition addresses a different question on the nature of synergies: (i) How many synergies can humans have? (ii) How do we learn and develop synergies? (iii) How do we use synergies? An example numerical simulation is presented and analyzed to clarify the hypothesis propositions. The expansion hypothesis is contextualized with respect to the existing literature on motor synergies both in healthy and impaired individuals, as well as other prominent theories in human motor control and development. The expansion hypothesis provides a novel framework to better comprehend and explain the nature, use and evolution of human motor skills. Significance StatementUnderstanding how humans effortlessly control coordinated movements has been a long-standing challenge in neuroscience. This research introduces the "expansion hypothesis", a new framework to explain how we develop, learn, and use motor synergies - coordinated activities of multiple features such as joints and muscles - that simplify movement control. By breaking down the nature of these synergies into mechanical, developmental, and behavioral aspects, this study offers novel insights into how our brains and bodies work together to achieve fluid motion. This work not only advances the scientific understanding of human motor control but also has potential implications for improving rehabilitation strategies for individuals with movement impairments and for developing more dexterous human-inspired robotic control techniques.

neuroscience↗