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Ventura, P. C.

Publications and source records attributed to Ventura, P. C..

2 recordsLinked to original sources

Short-term forecasts of Aedes aegypti relative abundance to enhance mosquito control situational awareness

Conventional mosquito surveillance typically relies on contemporaneous data, making it challenging to anticipate future vector surges. To support proactive vector management, this study evaluates a multi-model forecasting framework designed to generate probabilistic 1-to 4-week-ahead forecasts of Aedes aegypti relative abundance per trap night. The framework was validated using multi-year surveillance data across four US jurisdictions spanning varied environments (from subtropical to temperate and arid). We found that an ensemble approach aggregating statistical and machine learning models generally achieved the best performance across all locations and forecast horizons. Relative forecast performance improved as the forecast horizon extended from 1 to 4 weeks ahead. The most challenging data to forecast were primarily restricted to low mosquito activity periods or atypical population peaks with unusual timing or magnitude. While full integration into routine vector management workflows represents a long-term process requiring operational adaptation, this work advances forecasting research and establishes a baseline for translating these approaches into real-time applications for public health authorities, with downstream effects in mitigating the risks of mosquito-borne diseases.

ecology↗

Evaluating Field Trial Designs for Genetically Modified Mosquito Interventions: An In-Silico Simulation Approach

Mosquito control strategies based on the mass release of modified males, such as genetically modified mosquitoes (GMMs), aim to suppress wild populations by impairing reproduction. Evaluating these interventions requires resource-intensive field trials, but a lack of standardized implementation practices, particularly regarding release ratios of modified males to wild female mosquitoes and trial timing, has led to variable outcomes. This studys objective is to propose a modeling tool for the "in-silico" simulation of trial designs before field implementation. To this aim, we developed an agent-based model of mosquito population dynamics. As a case study, we calibrated the model using 2019-2023 Aedes aegypti surveillance data from Miami-Dade County, Florida, and compared two GMM trial designs as illustrative examples. Our results show that depending on the implementation choices (e.g., trial start date and duration, release ratio), trials yield highly variable outcomes. For example, changing the start date while fixing all other implementation details can lead to effectiveness between 50% and 90%. Our findings suggest that "in-silico" simulation is a valuable tool for improving trial protocol design, allowing stakeholders to test strategies and reduce outcome uncertainty before committing to a fieldwork experiment.

ecology↗