Alterations of Task-based fMRI Topology Underlying Cognitive Flexibility and Stability in Schizophrenia
Recently, it has been suggested that brain dysconnectivity in patients with schizophrenia contributes to the wide-ranging cognitive deficits that characterize the disorder. Graph theoretical analysis offers a unique method for studying how architectural alterations in large- scale brain networks may contribute to cognitive impairments in these patients. Implementing this technique, we analyzed the functional brain activity during a predictive switch-drift task from 21 patients with schizophrenia and 22 matched healthy controls. We specifically calculated task-based global graph measures for the functional networks that were activated during expected events, events requiring a flexible updating of predictions, and events that required the stabilization of predictions. By implementing Bayesian multivariate generalized linear models, we found functional network alterations during all event types, which indicated less centralized, less integrated, and simultaneously less segregated network topology in patients with schizophrenia compared to controls. In addition, the rate of correctly detected switches, requiring flexible updating of internal models, predicted global graph measures differently for patients compared to controls. In particular, lower cognitive flexibility in patients was associated with reduced integration of functional networks. Overall, the results indicate an adaptation of network topologies, resulting in less optimal network organization in patients with schizophrenia compared to healthy controls.