Biology subjects

Torell, F.

Publications and source records attributed to Torell, F..

3 recordsLinked to original sources

bioRxiv2024

Local muscle pressure stimulates the principal receptors for proprioception

Proprioception plays a crucial role in motor coordination and self-perception. Muscle spindles are the principal receptors for proprioception. They are believed to encode muscle stretch and signal limb position and velocity. Here, we applied percutaneous pressure to a small area of extensor muscles at the forearm while recording spindle afferent responses, skeletal muscle activity and hand kinematics. Three levels of sustained pressure were applied on the spindle-bearing muscle when the hand was relaxed and immobile ( isometric condition) and when the participants hand moved rhythmically at the wrist. As hypothesized to occur due to compression of the spindle capsule, we show that muscle pressure is an adequate stimulus for human spindles in isometric conditions, and that pressure enhances spindle responses during stretch. Interestingly, release of sustained pressure in isometric conditions lowered spindle firing below baseline rates. Our findings urge a re-evaluation of muscle proprioception in sensorimotor function and various neuromuscular pathologies. HIGHLIGHTSO_LILocal muscle pressure is an adequate stimulus for spindles in isometric conditions C_LIO_LIRelease of pressure in isometric conditions lowers spindle firing below baseline rates C_LIO_LILocal muscle pressure enhances spindle afferent responses during muscle stretch C_LI

neuroscience↗

bioRxiv2022

Goal-directed modulation of stretch reflex gains is reduced in the non-dominant upper limb

Most individuals experience their dominant arm as being more dexterous than the non-dominant arm, but the neural mechanisms underlying this asymmetry in motor behaviour are unclear. Using a delayed reach task, we have recently demonstrated strong goal-directed tuning of stretch reflex gains in the dominant upper limb of human participants. Here, we used an equivalent experimental paradigm to address the neural mechanisms that underlie the preparation for reaching movements with the non-dominant upper limb. We found only minor goal-directed differences in the short latency stretch reflex of the non-dominant limb. There were consistent effects of load, preparatory delay duration and target direction on the long latency stretch reflex. However, by comparing stretch reflex responses in the non-dominant arm with those previously documented in the dominant arm, we demonstrate that goal-directed tuning of short and long latency stretch reflexes is markedly weaker in the non-dominant limb. The results indicate that the motor performance asymmetries across the two upper limbs is partly due to the more sophisticated control of reflexive stiffness in the dominant limb, likely facilitated by the superior goal-directed control of muscle spindle receptors. Our findings therefore suggest that independent fusimotor control plays a role in determining performance of complex motor behaviours and support existing proposals that the dominant arm is better supplied for executing more complex tasks, such as trajectory control. Key pointsO_LIMost of us routinely rely on the dominant arm to perform more complex and demanding motor tasks, but the mechanisms enabling the superior motor performance of the dominant limb are unclear. C_LIO_LIA better understanding of the motor asymmetry across the two arms might provide key insight into core sensorimotor principles. C_LIO_LIThis study shows that goal-directed tuning of short and long latency stretch reflexes in the non-dominant arm is markedly weaker than in the dominant arm. C_LIO_LIOur results suggest that the more sophisticated control of reflexive stiffness in the dominant limb, likely facilitated by superior fusimotor control, partly underpins the laterality of motor performance. C_LI

neuroscience↗

bioRxiv2022

Assistive loading promotes goal-directed tuning of stretch reflex gains

Voluntary movements are prepared before they are executed. Preparatory activity has been observed across the CNS and recently documented in first order neurons of the human PNS i.e., in muscle spindles. The changes seen in these sensory organs suggest that the independent modulation of stretch reflex gains may represent an important component of movement preparation. The aim of the current study was to further investigate the preparatory modulation of short- and long-latency stretch reflex responses ( SLR and LLR) of the dominant upper limb. Specifically, we investigated how different target parameters (target distance and direction) affect the preparatory tuning of stretch reflex gains in the context of goal-directed reaching, and whether any such tuning depends on preparation duration and the direction of background loads. We found that target distance produced only small variations in reflex gains. In contrast, both SLR and LLR gains were strongly modulated as a function of target direction, in a manner that facilitated the upcoming voluntary movement. This goal-directed tuning of SLR and LLR gains was present or enhanced when the preparatory delay was sufficiently long (>250 ms) and the homonymous muscle was unloaded i.e., when a background load was first applied in the direction of homonymous muscle action (assistive loading). The results extend further support for a relatively slow-evolving process in reach preparation that functions to modulate reflexive muscle stiffness, likely via the independent control of fusimotor neurons. Such control can augment voluntary goal-directed movement and is triggered or enhanced when the homonymous muscle is unloaded. Significance StatementIt is well-known that movement preparation improves motor performance. That is, briefly delaying the onset of a goal-directed movement can significantly benefit the overall quality of movement. However, the mechanisms underlying movement preparation remain unclear. In this study we examined the preparatory modulation of short- and long-latency stretch reflex responses in the dominant upper limb. We found that goal-directed tuning of stretch reflex gains is consistently triggered or enhanced in cases where preparation is sufficiently long (>250 ms) and a background - assistive- load is first applied in the direction of homonymous muscle action. A better understanding of movement preparation will likely also benefit the development of rehabilitation regimes and movement augmentation devices.

neuroscience↗