Biology subjects

Tang, D.

Publications and source records attributed to Tang, D..

3 recordsLinked to original sources

bioRxiv2019

Pharmacokinetics Modeling and Simulation of Voriconazole Dosing and Safety in Patients with Liver Cirrhosis

Voriconazole is used to treat invasive fungal disease and the optimal dose regimens are still unknown in cirrhotic Patients. The aim of this study was to determine the safety, to describe pharmacokinetics characteristics, and to optimize dosage regimens of voriconazole in cirrhotic patients. Data pertaining to voriconazole were collected retrospectively and analyzed using a population pharmacokinetics model. A total of 219 trough concentrations (Cmin) from 120 patients were analyzed. Voriconazole-related adverse events developed in 29 patients, with 69.0% of AEs developing within the first week after voriconazole treatment. The threshold Cmin for AEs was 5.12 mg/L. A one-compartment model with first-order absorption and elimination adequately described the data. The Child-Pugh class was the only covariate in final model. Voriconazole clearance in patients with Child-pugh A and B cirrhosis (CP-A/CP-B) and Child-pugh C cirrhosis (CP-C) were 1.79 L/h and 0.99 L/h, respectively, the volume of distribution was 159.6 L, and the oral bioavailability was 91.8%. The elimination half-life was significantly extended for up to 61.8 - 111.7 h in cirrhotic patients. Model-based simulations showed that the appropriate maintenance doses are 75 mg/12 h and 150 mg/24 h intravenously or orally for CP-A/CP-B patients, and 50 mg/12 h and 100 mg/24 h intravenously or orally for CP-C patients. The results support voriconazole maintenance doses in LC patients should be reduced to one-fourth for CP-C patients and to one-third for CP-A/CP-B patients compared to that for patients with normal liver function. Monitoring Cmin early could be a useful strategy to ensure the safety.

pharmacology and toxicology↗

bioRxiv2019

Bacterial Glycogen as a Durable Energy Reserve Contributing to Persistence: An Updated Bibliography and Mathematical Model

Glycogen is conventionally viewed as a transient energy reserve that can be rapidly synthesized for glucose accumulation or mobilized for ATP production and blood glucose homeostasis in higher organisms. However, this understanding is not completely applicable to prokaryotes due to glycogen structural heterogeneity. A number of studies have noted that glycogen with short average chain length gc in bacteria has the potential to degrade slowly, which might prolong bacterial survival in the environment and thus enhance potential for transmission to new hosts. This phenomenon has been examined over the past few years and called the durable energy storage mechanism hypothesis (DESM). In this updated bibliography, we summarize recent progress and provide a mathematical model of glycogen as a durable energy reserve.

microbiology↗

bioRxiv2018

QTL mapping of leaf angle on eight nodes in maize enable the optimize canopy by differential operating of leaf angle at different levels of plant

Leaf angle (LA) is one of the most important canopy architecture related traits of maize (Zea mays L.). Currently, there is an urgent need to elucidate the genetic mechanism of LA at canopy-wide levels for optimizing dense-planting canopy architecture. In present study, one RIL population derived from two parent lines which show distinct plant architecture was used to perform QTL mapping for LA at eight leaves below the tassel under three environments. Dozens of QTL for LA at eight leaves were identified, which were mapped on all maize chromosomes except for the tenth chromosome. Among them, there were nine common QTL as they were identified for LA more than 1 leaves or in two or three environments. And individual QTL could explain 1.29% - 20.14% of the phenotypic variation and affect LA of 1-8 leaves, including qLA5.1 affected LA of all eight leaves, qLA3.1 affected LA of the upper leaves (1stLA to 4thLA), and qLA9.1 could affect LA of the lower leaves (5thLA to 8thLA). Furthermore, the results indicated that the genetic architecture of LA at eight leaves was different. Specifically, 8thLA was mainly affected by major and minor QTL; 1stLA, 4thLA and 5thLA were affected by epistatic interactions beside major and minor QTL; while the other four LAs were simultaneously affected by major QTL, minor QTL, epistatic interactions and environments. These results provide a comprehensive understanding of genetic basis of LA at canopy-wide levels, which will be beneficial to design ideal plant architecture under dense planting in maize. Author contribution statementJ. L. and D. T. designed and supervised the study, D. T., Z.C., J.N., Q.J., P.L., L.W., J.Z., C.L. performed the phenotypic data collection. D. T. analyzed the data and drafted the manuscript, D. T. and Z.C. revised and finalized the manuscript. All the authors read and approved the manuscript. Key messageDozens of QTL for leaf angle of eight consecutive leaves were identified in the RIL population across three environments, providing the information that optimization of canopy architecture at various canopy levels.

plant biology↗